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A series of disruptive technologies emerged in the Fourth Industrial Revolution, which on the one hand had a profound impact on urban space and social life, and on the other hand provided new data, new methods and new technologies for the built environment / human settlement related research. Combining the observation of the new coronavirus pneumonia as a public health event and the theme of future human settlements driven by disruptive technologies, six perspectives for current research situation criticism and future research prospects have been proposed in this paper:(1) Urban big data has emerged, and it will be more profoundly applied in the built environment academia and industry;(2) Our understanding on cities is still limited, and urban science is still in its infancy. How to improve the scientific nature of urban research, especially urban spatial research? (3) Emphasize the use of new data, new methods, and new technologies to study "new" cities, that is, "the new science of cities"; (4) The research of healthy cities needs to establish a substantial cooperation between built environmental disciplines and public health disciplines, and embrace smart technologies in the background of digital health; (5) Smart technology effectively supports city operations and residents' living condition, and built environmental disciplines should actively explore the application of emerging technologies; (6) The discipline of built environment should actively explore the spatial prototype of the future city, and support future built environment design based on Spatial Intervention, Place Making and Digital Innovation (SIPMDI).