The Fourth Industrial Revolution, formed by Internet industrialization and industrial intelligence, is profoundly affecting and changing our cities with a series of disruptive emerging technologies, especially information and communication technologies (ICTs). Conventional design approaches such as spatial intervention will not be capable enough to deal with the spatial needs of people’s daily life. In this context, a new future-oriented design concept of "Spatial Intervention, Place Making and Digital Innovation (SIPMDI)" is proposed, aiming to integrate ICTs into designs, and shape high quality living environment. The concept, process, application scenarios and characteristics, as well as related cases are illustrated in this paper.